On June 6, 1999 in Madrid, Spain, Working Group 11 of ISO TC20 approved the international aerospace quality standard for publication.

First release in October 1999 was followed by 2001/A revision and 2004/B revision to provide harmonization with ISO 9001:2000 structure and to define additional aerospace requirements.

AS/EN 9100 was upgraded to 2009/C revision in January 2009 to adapt the ISO 9001:2008 changes and also to include the defense sector.

The latest 2016/D revision of the standard was published in September 2016 to keep the same line with ISO 9001:2015 which has considerable structural and content changes and to define the up to date aerospace/defense requirements.

All audits shall be performed in accordance with AS/EN 9100:2016 version by June 2017 and all AS/EN 9100:2009 version cerificates shall no longer be valid by September 2018.